Effects of the Association of Periodontitis and Type 1 Diabetes Mellitus Induced on Periodontal Tissues and the Duodenal Mucosa of Wistar Rats.

Forty Wistar rats were used: (1) control group (CG); (2) group of periodontal disease (PD); (3) type 1 diabetes mellitus group (T1DM); (4) type 1 diabetes mellitus + periodontal disease group (T1DM + PD). In groups T1DM and T1DM + PD, T1DM induction was performed with the administration of streptozotocin (STZ) 80 mg/kg intraperitoneal body weight. The PD and T1DM + PD groups were submitted to PD induction with ligation. After the experimental phase and euthanasia, histological, radiographic, and morphological analyses were performed. For data analysis, was used the one-way ANOVA and post-test Tukey. The T1DM + PD group had a significantly higher level of fasting blood glucose compared to the other groups. In radiographic and histomorphometric analyses, the T1DM + PD group showed greater alveolar bone loss compared to the control group. The T1DM + PD group showed greater osteoclastic activity compared to the control, T1DM, and PD groups and exhibited an intense inflammatory infiltrate, most of which were PMN, being that the amount of this group of cells (PMN) was significantly greater than the PD group. The heights of the intestinal villi were statistically higher in the PD, T1DM, T1DM + PD groups, compared to the control. Regarding the height of the crypt, only the T1DM and T1DM + PD groups were significantly higher compared to the other groups. Association of diabetes and periodontal inflammation increased the deleterious effects on bone tissue and adverse effect on the permeability of the duodenal mucosa.

Study of l-tryptophan in an experimental model of depression caused by alzheimer's disease / Estudo do l-triptofano na depressão ocorrida pela doença de alzheimer em modelo experimental

ABSTRACT Alzheimer's is a neurodegenerative disease characterized by cognitive impairment commonly associated with mood disorders, which trigger depressive reactions and compromise mental performance and functionality. The objective of the present study was to verify the effects of L-tryptophan and to analyze motor behavior in an experimental model of depression caused by the Alzheimer's disease process. The sample consisted of 40 Wistar rats divided equally into two groups, 20 animals treated with L-tryptophan and 20 control animals. Both groups received spatial memory training in the water maze task and were submitted to stereotaxic surgery to induce dementia. The treated group achieved better spatial memory activity than the control group in the Morris water maze. Treatment with L-tryptophan had beneficial effects on reactive memory.

RESUMO O Alzheimer é uma doença neurodegenerativa caracterizado pelo comprometimento cognitivo comumente associado a transtornos do humor, os quais desencadeiam reações depressivas, comprometem o desempenho mental e a funcionalidade. O objetivo do presente estudo foi verificar os efeitos do L-triptofano e analisar o comportamento motor em modelo experimental com depressão decorrente do processo de Alzheimer. A amostra foi composta por 40 ratos da linhagem wistar divididos igualmente em dois grupos, 20 animais tratados com L-triptofano e 20 animais pertencentes ao grupo controle. Ambos os grupos receberam treinamento da memória espacial no later water maze e foram submetidos à cirurgia estereotáxica para indução demencial. Verificou-se através do labirinto aquático de Morris que o grupo tratado obteve atividade para memória espacial melhor do que o grupo controle. O tratamento com L-triptofano demonstrou melhor benefício na memória reativa.